Introduction and Objective: As the largest organ of the body, the
skin also has great duties, the most important of which is to create a barrier against pathogenic microorganisms and all factors that intend to harm the body. Several reasons can cause this protective barrier to break such as burns, traumas, diabetic wounds, surgical wounds. Related to
skin injury, Pseudomonas aeruginosa and Staphylococcus aureus play important roles and cause of wound infections in the most reports.Until recently, wound skins were treated with
skin replacements (autograft and xenograft, etc.), using ointments or traditional treatments, but since these treatments did not completely heal the wound or left many wound scars and complications,
tissue engineering and
regenerative medicine rushed to help these patients. The use of sprays, dressings, and artificial
skin are among the types of these remedies that are considered as a new treatment. One of the principles of treating all
skin wounds, is to make the wound site clean that is provided by
tissue engineering products. in this review article, new treatments based on
tissue engineering are introduced.Method: An electronic search was conducted in Science Direct, Scopus, PubMed and Google scholar search engine with English keywords including: tissue engineering, regenerative medicine, wound healing, skin. Combined search of keywords was done using Boolean operators AND and OR. Data analysis was done qualitatively.Results: Bioengineered skin, temporary
skin substitute (i.e.BiobraneR,
skin substitute, Endofoam™ Dermal Template, EZDerm and etc.) & permanent
skin substitute (i.e. AlloDerm Regenerative Tissue Matrix AlloMax™ Surgical Graft, AminoFix)
skin substitute (acting like a dressing), sprays (i.e. Dermoplast, Alocane Emergency Burn Gel and etc.), dressing (i.e. Burnshield) are equipments that are currently used as treatment.Conclusion: Over the past few decades, various technologies have been developed for optimal wound healing. Tissue engineering and
regenerative medicine offer wide opportunities for the treatment of
skin diseases. in this review we find that,
tissue engineering and
regenerative medicine have always been at the forefront in providing possible treatment solutions and it seems that in future, newer ways of treatment are expected. the production of commercial
tissue engineering products has led to the development and recognition of many important principles of wound healing, which can be useful for the development of other
tissue engineering products.