A review on advances in tissue engineering and regenerative medicine to wound healing

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 63

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شناسه ملی سند علمی:

HUMS04_117

تاریخ نمایه سازی: 3 خرداد 1402

چکیده مقاله:

Introduction and Objective: As the largest organ of the body, the skin also has great duties, the most important of which is to create a barrier against pathogenic microorganisms and all factors that intend to harm the body. Several reasons can cause this protective barrier to break such as burns, traumas, diabetic wounds, surgical wounds. Related to skin injury, Pseudomonas aeruginosa and Staphylococcus aureus play important roles and cause of wound infections in the most reports.Until recently, wound skins were treated with skin replacements (autograft and xenograft, etc.), using ointments or traditional treatments, but since these treatments did not completely heal the wound or left many wound scars and complications, tissue engineering and regenerative medicine rushed to help these patients. The use of sprays, dressings, and artificial skin are among the types of these remedies that are considered as a new treatment. One of the principles of treating all skin wounds, is to make the wound site clean that is provided by tissue engineering products. in this review article, new treatments based on tissue engineering are introduced.Method: An electronic search was conducted in Science Direct, Scopus, PubMed and Google scholar search engine with English keywords including: tissue engineering, regenerative medicine, wound healing, skin. Combined search of keywords was done using Boolean operators AND and OR. Data analysis was done qualitatively.Results: Bioengineered skin, temporary skin substitute (i.e.BiobraneR, skin substitute, Endofoam™ Dermal Template, EZDerm and etc.) & permanent skin substitute (i.e. AlloDerm Regenerative Tissue Matrix AlloMax™ Surgical Graft, AminoFix) skin substitute (acting like a dressing), sprays (i.e. Dermoplast, Alocane Emergency Burn Gel and etc.), dressing (i.e. Burnshield) are equipments that are currently used as treatment.Conclusion: Over the past few decades, various technologies have been developed for optimal wound healing. Tissue engineering and regenerative medicine offer wide opportunities for the treatment of skin diseases. in this review we find that, tissue engineering and regenerative medicine have always been at the forefront in providing possible treatment solutions and it seems that in future, newer ways of treatment are expected. the production of commercial tissue engineering products has led to the development and recognition of many important principles of wound healing, which can be useful for the development of other tissue engineering products.

نویسندگان

Hamidreza Ghaderi Jafarbeigloo

Student research center committee, Fasa university of medical sciences, Fasa, Iran- Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Fariba Noori

Student research center committee, Fasa university of medical sciences, Fasa, Iran- Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Mozhgan Jirenezhadian

Student research center committee, Fasa university of medical sciences, Fasa, Iran- Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Arash Goodarzi

Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran