Vitamin D supplement for COVID-۱۹: A Systematic Review

Introduction and objective: COVID-۱۹ is a respiratory disease that can cause inflammation in respiratory tracts; the symptoms include fever, cough, and maybe respiratory failure. Corona had been a global health threat since ۲۰۱۹. More than ۶۵۵ million people in the world were infected with coronavirus and the maturity is close to ۶.۷ million people in the world. Also, nearly ۱۳ million people were vaccinated in the world. New cases per day are close to ۷۰۰,۰۰۰. Although COVID-۱۹ has been controlled by vaccination, however, it seems that coronavirus will continue to threaten public health. So, we need some protocols to lower the risk of getting infected and mortality. Studies were shown using supplements will increase the strength of the immune system; such as vitamin D supplements. Vitamin D is a hormone that moderate immune system against different upper respiratory infections. So, it has an important role in preventing the respiratory system from infections. And also, it can stop hyper-inflammatory responses and expedites the healing process in the lung tissue.Method: Web of Science, PubMed, and Google Scholar databases were used to identify articles published in related fields in all languages.Result: In our review, we identified that there is a positive trend between vitamin D levels and an increased risk of death in people infected with the coronavirus. Necessary investigations were carried out on some people who tested positive for Covid-۱۹, and the rate of ICU admission and the rate of death in them were studied. It also showed that the mean level of vitamin D was lower in patients with positive covid-۱۹ compared with negative ones. Vitamin D receptors effect on reducing respiratory viruses by effecting on creating a cellular cathelicidin. Cathelicidin stimulates the expression of cytokines to help the body's immune system. Overall, by checking out studies, recognized that vitamin D supplements can be recommended to reduce the danger of COVID-۱۹ disease.Conclusion: vitamin D is an effective supplement for respiratory viruses such as coronavirus which can reduce mortality and ICU admission and also can prevent infection with covid-۱۹.

کلیدواژه ها:

Covid-۱۹ ، Vitamin D ، Corona ، Coronavirus ، Vitamin D supplement