methylated septin ۹ in various stages of CRC-A meta analysis Study

Introduction: The prevalence of colorectal cancer (CRC) is increasing, and early detection in low stages is very important. One of these markers is ۹-methylated septin, whose expression level is related to different degrees of colorectal cancer. As a result, in this review study, we tried to Investigating the expression level of methylated septin ۹ gene in different grades of colorectal cancer.Method: The present study was a systematic review and synthesis of quantitative evidence. The primary keywords were published in reliable databases such as Pubmed, Google schoolar, Elsevier, Wiley in English were searched until the end of ۲۰۲۲. Two authors independently examined the articles in terms of data extraction, inclusion criteria, and quality assessment of the articles, and the meta-aggregation method synthesized the findings.Result: Our result on ۱۳ studies shows that total number of participants with colon cancer was ۱,۹۴۳ ( ۵۷.۸ % male and ۴۲.۲ % Female) , and the average age of the patients was ۶۲.۷۵ years. The average Septin ۹ was positive ۶۵.۴ %. In Our study positive detection rate overall, respectively for ۰ stage ۵۵.۱۴% , I stage ۵۱.۲۱% ., II stage ۷۰.۳۷% , III stage ۶۴.۵۴% , IV stage ۹۹.۹۹% and for unknown ۶۷.۸۳% . The highest percentage based on different stages of cancer was related to stage IV (۹۹.۹۹%) and the lowest was related to stage I cancer (۵۱.۲۱%) .Conclusion: The studies considered in this article show that methylated septin-۹ is a suitable biomarker for detecting colorectal cancer. Another important point is the relationship between the expression level of septin-۹ and different degrees of colorectal cancer, so that in stage ۰ and ۱, the lowest level of expression and in the stage ۴ The highest level of expression was seen.