Salivary Gland Tumors in Iran: A Systematic Review of ۲۸۷۰ Cases Based on the New WHO Classification

Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.Methods: The systematic literature search was performed in EMBASE, Scopus, PubMed MEDLINE, Google Scholar, Scientific Information Database (SID), and Magiran; we searched for "salivary gland," "tumor," "prevalence," and "Iran" until ۱ March ۲۰۲۱. The studies included were written in the English and Farsi languages. The weighted mean prevalence of SGTs was calculated as prevalence (%) * (N/the sum of all N). We used the unpaired Two-sample T-test to compare the weighted means.Results: A total of ۱۷ studies, including ۲۸۷۰ patients, were selected for the data synthesis. The weighted mean prevalence of benign and malignant tumors was ۶۶% (۹۵% CI: ۵۹-۷۳) and ۳۴% (۹۵% CI: ۲۷-۴۱), respectively. The patients' mean age was reported in ۱۰ out of the ۱۷ studies. The weighted mean age of the patients was ۴۰ (۹۵% CI: ۳۷-۴۲) and ۴۹ (۹۵% CI: ۴۳-۵۵) years for benign and malignant tumors, respectively (P=۰.۰۱). Pleomorphic adenoma (PA), followed by Warthin's tumor (WT), was the most prevalent benign tumor. Moreover, the most common malignant tumors were mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (AdCC).Conclusion: More than one-third of SGTs in Iran were malignant, which is higher than the reports from Middle Eastern countries. Information about risk factors and the burden of SGTs in Iran is insufficient. Thus, further well-designed longitudinal studies are warranted.

کلیدواژه ها:

Adenoid Cystic Carcinoma ، Classification ، Mucoepidermoid carcinoma ، Neoplasms ، Pleomorphic adenoma ، Prevalence