Reproductive Toxicity of Mycotoxins

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 220

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تاریخ نمایه سازی: 24 اردیبهشت 1402

چکیده مقاله:

Introduction: Mycotoxins are toxic secondary metabolites formed by some molds fungi species in foods with vary in structure and biochemical effects that be able to cause mycotoxicosis. Multiple studies point to the association between their exposure and reproductive toxicity in humans and animals. This study was to reveal and understand the effect of mycotoxins on causing male and female infertility.Methods: This study is a review of the results of studies published in English based on electronic sources (PubMed,MEDLINE,Embase).Results: Studies have shown that some mycotoxins may cause mutations in the gametes genome, act as endocrine disruptors, damage to sex organs, disruption of hormone synthesis and consequences related to infertility. Exposure to the aforementioned mycotoxins in animal models showed adverse effects on the maturation ۱eydig۱ and ۱eydig cell in male and proliferation and apoptotic indices of ovarian follicles and uterine cells. Similarity of zearalenone to estrogen has been linked to precocious puberty in girls. Aflatoxin B۱ caused poor sperm quality, fumonisin B۱ linked to the onset of puberty, semen quality, fertility rates and testicular morphology in male. Deoxynivalenol effects on spermatogenesis associated with testosterone deficiency, and ochratoxin A has been linked to be teratogenic, reduce birth weight and craniofacial abnormalities.Conclusion: Some fungi, in addition to causing harmful infections to reproductive tissues, by producing mycotoxins in many foods, cause adverse effects such as suppression of the immune system, carcinogenesis, metabolic disorders, and are also effective in causing infertility (reproductive toxicity) in humans in various possible ways.


Zahra Moniripour

General medicine student, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Seyed Ali Aghili

General medicine student, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Seyed Reza Aghili

Invasive Fungi Research Center/Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran