The Effect of a HIIT Training Course on the Expression of PGC-۱α, SIRT۱, and SIRT۳ Genes in the Cardiac Tissue of Elderly Female Rats
محل انتشار: مجله کشت ها و گردش خون، دوره: 2، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 73
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_QJVC-2-4_014
تاریخ نمایه سازی: 16 اردیبهشت 1402
چکیده مقاله:
Background and Aim: Exercise improves the function of mitochondrial proteins and enzymes in old age. This study aimed to investigate the effect of a high-intensity interval training (HIIT) training course on the expression of PGC-۱α, SIRT۱, and SIRT۳ genes in the cardiac tissue of elderly female rats.
Materials and Methods: In this experimental study, ۱۴ female Sprague-Dawley rats with a mean age of ۱۶-۱۸ months and a weight range of ۲۸۰-۳۲۰ g were randomly divided into ۲ groups of ۷, including the control group and the HIIT training group. The experimental group performed HIIT training for ۸ weeks and ۵ days a week with an intensity of ۸۵%-۱۱۰% VO۲max. Forty-eight hours after the last training session, rats were anesthetized by intraperitoneal injection of ketamine and xylazine, and the target tissue was immediately removed for examination. Shapiro-Wilk statistical test and one-way analysis of variance in SPSS software v. ۲۲ analyzed the findings (P≥۰.۰۵).
Results: The results showed that the expression of PGC-۱α, SIRT۱, and SIRT۳ genes increased in the cardiac tissue of the experimental group compared to the control group after ۸ weeks of HIIT training, but this increase was not significant (P≤۰.۰۵).
Conclusion: It seems that in elderly conditions, exercise from pathways other than PGC-۱α improves mitochondrial function. However, further research is needed on the effect of HIIT exercise on the expression of these genes in cardiac tissue.
کلیدواژه ها:
نویسندگان
Khadijeh Hassanpour
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
Bahram Abedi
Department of Physical Education,Tehran North Branch, Islamic Azad University.
Lida Moradi
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran.
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :