Leptin placental expression in pregnant women with diabetes : A Case control study

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 138

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شناسه ملی سند علمی:

JR_JOGCR-8-2_011

تاریخ نمایه سازی: 9 اردیبهشت 1402

چکیده مقاله:

Background: One of the worldwide healthcare problems is Diabetes mellitus (DM), and the prevalence of this disease increases steadily, particularly in pregnancy. The several metabolic disorders in the pregnancy were revealed by the placenta. The pathogenesis of diabetes mellitus is associated with hyperglycemia, insulin resistance, and oxidative stress, and it negatively impacts the mother-placenta-fetus system. This research aims to compare the amount of leptin expression, as well as its score and intensity, in the placentas of women with diabetes with those of healthy controls.Materials and methods: In this work, we used a case-control methodology. Thirty women were diagnosed with diabetes and were placed in one group, while the other ۴۰ served as a comparison. Primary monoclonal antibodies were used for the immunohistochemical analysis of leptin (Abcam, UK).Results: The patients group showed the greatest percentage (۲۳%) of placental expression of leptin. The expression of leptin was high in around ۵۳% of the patient population. The intensity of leptin expression was significantly higher in DM patient than control groups (P>۰.۰۵). About ۷۷% of patients group had moderate intensity of leptin expression, while ۳۷.۵% of control group had no leptin expression.Conclusion: Diabetes mellitus was related with alterations in expressions of leptin as metabolic placental factor. Leptin may affect the pregnancy diverse disorders and pregnancy outcome.

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نویسندگان

Zinah hammad

Collage of Medicine, University of Babylon, babil, Iraq

Ban J. Edan

Department of Physiology, Collage of Medicine, University of Babylon, Babil, Iraq

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