Leptin placental expression in pregnant women with diabetes : A Case control study
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 138
فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JOGCR-8-2_011
تاریخ نمایه سازی: 9 اردیبهشت 1402
چکیده مقاله:
Background: One of the worldwide healthcare problems is Diabetes mellitus (DM), and the prevalence of this disease increases steadily, particularly in pregnancy. The several metabolic disorders in the pregnancy were revealed by the placenta. The pathogenesis of diabetes mellitus is associated with hyperglycemia, insulin resistance, and oxidative stress, and it negatively impacts the mother-placenta-fetus system. This research aims to compare the amount of leptin expression, as well as its score and intensity, in the placentas of women with diabetes with those of healthy controls.Materials and methods: In this work, we used a case-control methodology. Thirty women were diagnosed with diabetes and were placed in one group, while the other ۴۰ served as a comparison. Primary monoclonal antibodies were used for the immunohistochemical analysis of leptin (Abcam, UK).Results: The patients group showed the greatest percentage (۲۳%) of placental expression of leptin. The expression of leptin was high in around ۵۳% of the patient population. The intensity of leptin expression was significantly higher in DM patient than control groups (P>۰.۰۵). About ۷۷% of patients group had moderate intensity of leptin expression, while ۳۷.۵% of control group had no leptin expression.Conclusion: Diabetes mellitus was related with alterations in expressions of leptin as metabolic placental factor. Leptin may affect the pregnancy diverse disorders and pregnancy outcome.
نویسندگان
Zinah hammad
Collage of Medicine, University of Babylon, babil, Iraq
Ban J. Edan
Department of Physiology, Collage of Medicine, University of Babylon, Babil, Iraq
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :