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A photo-electro-responsive fluorometric assay based on triazine covalent organicframework/polyoxometalate heterojunction for highly sensitive neuropathy biomarker glutam ic acid detection

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 114

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شناسه ملی سند علمی:

ELECTROCHEMISTRY017_082

تاریخ نمایه سازی: 9 اردیبهشت 1402

چکیده مقاله A photo-electro-responsive fluorometric assay based on triazine covalent organicframework/polyoxometalate heterojunction for highly sensitive neuropathy biomarker glutam ic acid detection

Glutamic acid (Glu) is the most abundant excitatory neurotransmitter in the central nervous system, and an elevated level of Glu may indicate some neuropathological diseases. Herein, we developed a photoelectro-responsive fluorometric test strip-based peroxidase mimic activity of the triazine covalent organic framework/polyoxometalate heterojunction coated on paper for the effective luminol oxidation leading to a fluorogenic reaction and subsequently highly sensitive neuropathy biomarker glutamic acid detection. Results confirm the extensive π-electron delocalization, polarity, built-in electric field and high chemical stability for the as-prepared photo-electro-nanozyme. The increase in light harvesting and its separation and charge transfer were also confirmed by electrochemical and spectroscopic analysis. This photo-electronanonzymaticplatform revealed the sensitive detection of L-glutamic acid as a neurotransmitter in the linear range of 5 μM to 500 μM with a limit of detection (LOD) of 1.2 μM. The findings confirmed the safety and feasibility of the proposed photo-electro-nanonzymatic strategy for detecting L-Glu in biological samples as well as revealed satisfied selectivity in the presence of other biological molecules. This work opens a new insight into the development of signal-amplified test strips for point-of-care testing and disease monitoring.

کلیدواژه های A photo-electro-responsive fluorometric assay based on triazine covalent organicframework/polyoxometalate heterojunction for highly sensitive neuropathy biomarker glutam ic acid detection:

نویسندگان مقاله A photo-electro-responsive fluorometric assay based on triazine covalent organicframework/polyoxometalate heterojunction for highly sensitive neuropathy biomarker glutam ic acid detection

R Sedghi

Research Laboratory of Spectrometry & Micro and Nano Extraction, Department ofChemistry, Iran University of Science and Technology, Tehran, ۱۶۸۴۶-۱۳۱۱۴, Iran

K Dashtian

Research Laboratory of Spectrometry & Micro and Nano Extraction, Department ofChemistry, Iran University of Science and Technology, Tehran, ۱۶۸۴۶-۱۳۱۱۴, Iran

R Zare Dorabei

Research Laboratory of Spectrometry & Micro and Nano Extraction, Department ofChemistry, Iran University of Science and Technology, Tehran, ۱۶۸۴۶-۱۳۱۱۴, Iran

M Mohammadian

Research Laboratory of Spectrometry & Micro and Nano Extraction, Department ofChemistry, Iran University of Science and Technology, Tehran, ۱۶۸۴۶-۱۳۱۱۴, Iran