Bioinformatics Study of the Important Medicinal Plant: Salvia Genus

Elmira Ziya Motalebipour ۱۳۴*, Akbar Pirestani ۲۳۴ ۱Department of Agronomy and Plant Breeding, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. ۲Department of Animal Science, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. ۳Medicinal plants research center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. ۴Transgenesis Center of Excellence, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.                                                    *Corresponding Author E-mail:*[e-mail].   Received: ۲۰ October ۲۰۲۲                                                                                Accepted:  ۸  January  ۲۰۲۳   Abstract    Wide variety of medicinal plants showed the high amount of secondary metabolites. Flavonoids are a class of important secondary metabolites with medicinal benefits. One of the well-known traditional medicinal herb is Salvia genus with a broad diversity of flavonoids. Flavonol synthase (FLS) is one of the flavonoid biosynthesis-related gene were identified in some medicinal plant of Lamiacea family. However, flavonol synthase (FLS) have not been phylogeny and evolutionary divergence analyzed in different Saliva species. In this study, Arabidopsis thaliana FLS gene (NCBI accession NM_۱۲۰۹۵۱) was select and used as a query sequence for performing a BLASTN search. Six sequences query which was found by NCBI platform was selected for further analysis. Phylogenetic trees of full length sequences of different FLS gene of Salvia genus were constructed by the Maximum Likelihood method using MEGA software. This study may be the reference value for the genetic relationship among different FLS gene in Salvia genus species. This variation provides us the possibility the design the primer to achieve us to find the exact FLS gene and also showed the evolutionary divergence between salvia species.

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Keywords: Medicinal Plant ، Salvia genus ، phylogeny ، Evolutionary Divergence