Investigating the Effect of Natural Antioxidant Compounds on Infertility: A Systematic Review

Introduction: Infertility is widespread phenomenon which has been increasing steadily.Meanwhile, natural products can be effective in the treatment of infertility and can beconsidered as an alternative to traditional therapies. The present study aimed to investigate theeffects of antioxidant natural products on infertility.Search Method: Databases including PubMed, SID, Scopus and ProQuest were used as thesources of collecting related articles. The keywords included "Infertility" and "Antioxidant"based on MESH terms from ۲۰۱۲ to ۲۰۲۱. Interventional studies published in English andPersian were considered as eligible. The included studies were assessed for quality using “TheQuality Assessment Tool For Quantitative Studies (QATFQS).”Results: ۱۳ Studies met the inclusion criteria. As oxidative stress increases in individualssuffering from infertility, antioxidants have been known are the first barrier against oxidativestress. Antioxidant therapy may lead to improvement of sperm concentration. For instance,Angelica keiskei powder and Astragalus mongholicus extract could be effective in reducingthe level of infertility in males and females, respectively. Alpha-lipoic acid can improve semenparameters in terms of spermatozoa’s motility, morphology, and count. Also, the efficacy ofvitamin B۱۲ has been proven on semen quality as it increases sperm count and motility andreduces sperm DNA damage. A plant-based herbal medicine can treat infertility amongfemales. However, excessive intake of antioxidants may impose harmful impacts.Conclusion: It was indicated that infertility can be controlled by natural antioxidants.However, broader trials need to be conducted to confirm the efficacy of natural antioxidantboth in males and females. Taking advantage of combined methods is of a great importance.

کلیدواژه ها:

Infertility ، Antioxidant ، Oxidative Stress