Cyproheptadine-induced Giant cell hepatitis, a case report of a rare adverse event

Background: Giant-cell hepatitis (GCH) is a liver disease characterized histopathologically by multinucleated giant-cell hepatocytes. It can happen due to autoimmune disease, leukemia, toxins, and several drugs. Cyproheptadine is a first-generation antihistamine used to treat hypersensitivity reactions and appetite stimulation, among others.Case presentation: We present a case of a ۶۰-year-old woman who was referred to our hospital with acute jaundice and elevation of liver enzymes test. She didn’t have symptoms like fever, nausea, vomiting, weakness, GI bleeding, urticaria, and night sweating. Her vital signs were normal, and the only notable thing in her physical examination was the icterus sclera and skin. There were no signs of cirrhosis, she had an unremarkable past medical history and family history, she had never used alcohol in her life, viral markers and autoimmune tests were negative and the only drug she used recently was cyproheptadine for four days duration, one week before the onset of her condition, the ultrasonography and MRCP were normal. Chronic lobular hepatitis with giant cell transformation of hepatocytes indicates giant cell hepatitis was reported in her liver biopsy. She received hydrocortisone for three days. Her jaundice gradually disappeared, and her liver enzymes reduced dramatically. She was doing well after six months of follow-up.

کلیدواژه ها:

Cyproheptadine ، Giant cell hepatitis ، Drug reactions