Mechanism of Immune System for Evading and Escaping Cancer Cells: A Brief Review

For everyone, at all ages, to live healthy lives and to promote well-being, there should be good health and welfare at every stage of one's life, beginning at birth, whereas health and wellbeing are crucial. Strong health systems are essential for treating and preventing infectious illnesses as well as providing mothers and children with life-saving treatments. Having a well-trained health workforce, a robust infrastructure, a consistent supply of medicines and equipment, and the ability to quickly identify and address health emergencies are all components of a strong health system that provides care to those in need regardless of where they live or their financial situation. Under ideal conditions, cells of the innate immune system detect the danger signals provided by developing tumors. These signals induce hypertrophy, activate innate effector cells with antitumor activity, stimulate antigen-presenting cells on endogenous tumor cells or antigens, and then travel through lymph nodes to inform adaptive (T and B) lymphocytes.  Despite this excellent screening process, tumor presence suggests that the advanced tumor somehow avoids detection or overburdens the immune response. Cancer cells have developed a number of strategies that help them evade or resist the host's immune response. Through understanding the mechanism by which these cells evade the immune response, scientists hope to devise techniques to increase tumors immunity and the success of their treatment. In this review, we try to explain the ways and strategies that cancer cells have used to evasion from immune system in an attempt to understand these mechanisms and try to find standard solutions, therapeutic measures, and targets have developed or are investigated to promote tumor rejection.

کلیدواژه ها:

Tumors ، Evade ، Immune response