Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome

Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “chaca” is a medicinal plant used in Mexico for hypertension and empirical therapy.  In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome.Materials and Methods: For induction of metabolic syndrome, ۲۰% fructose was used, and it was administered in the water and food to male Wistar rats for ۱۲ weeks, after administering ethanol extract of B. simaruba intragastrically (۱۰۰ and ۲۰۰ mg/kg/day) for ۶ weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin ۱-۷ were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba.Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.

کلیدواژه ها:

blood pressure ، Bursera simaruba ، Hyperlipidemia ، Kidney Failure ، metabolic syndrome ، Obesity ، Oxidative stress