Antiviral Activity of Arnebia Euchroma and Amniotic Membrane against HSV-۱, Rotavirus, and Influenza Virus

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 148

فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_JIML-9-3_008

تاریخ نمایه سازی: 2 اسفند 1401

چکیده مقاله:

Background and Aims: Currently, there are antiviral chemicals used to treat viral infections accompanied by limitations such as high levels of toxicity and adverse effects in humans, the emergence of drug-resistant viral strains, low numbers, and limited diversity. Therefore, it is necessary to evaluate new photochemical to obtain new therapeutic methods. The present study was conducted to evaluate the antiviral activity of Arnebia Euchroma (A. Euchroma) extract, amniotic membrane, a mixture of A. euchroma extract and amniotic membrane and its carrier (comprised of Sesam and ostrich oil) against three different viruses, including Herpes simplex virus type ۱ (HSV-۱), influenza A, and rotavirus in-vitro. Materials and Methods: A methyl thiazolyl tetrazolium (MTT) assay was performed to evaluate the cytotoxic effect of the above compounds on Vero, MDCK, and MA-۱۰۴ cell lines. After the determination of non-toxic concentrations, Tissue culture infection dose ۵۰ (TCID۵۰) test was performed to determine antiviral activity. Results: Among all the above-mentioned compounds, the combination of A. euchroma extract and amniotic membrane at the highest non-toxic concentration for the cells had the highest antiviral activity against all three viruses, leading to ۱ log۱۰ TCID۵۰ reduction in influenza A and HSV-۱ titers and ۰.۶ log۱۰ TCID۵۰ reductions in rotavirus titer when compared to the virus control. Conclusions: The combination of A. euchroma and amniotic membrane can be considered a new antiviral agent to treat viral infections.

نویسندگان

سید مهدی ثقفی

Pharmaceutical Care Department, Firozabadi Hospital, Iran University of Medical Sciences, Tehran, Iran

احمد توکلی

Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

شهناز احمدی

Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran

سید حمیدرضا منوری

Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • . Aschale Y, Wubetu M, Abebaw A, Yirga T, Minwuyelet ...
  • . Ashkani-Esfahani S, Emami Y, Esmaeilzadeh E, Bagheri F, Namazi ...
  • . Chen X, Yang L, Zhang N, Turpin JA, Buckheit ...
  • . Pirbalouti A, Azizi S, Koohpayeh A, Golparvar A. Researches ...
  • . Sasaki K, Abe H, Yoshizaki F. In vitro antifungal ...
  • . Shen CC, Syu WJ, Li SY, Lin CH, Lee ...
  • . Annan K, Houghton PJ. Antibacterial, antioxidant and fibroblast growth ...
  • . Bali YY, Yilanci S, Yuzbasioglu M, Unlu RE, Orhan ...
  • . Zhang Y, Han H, Sun L, Qiu H, Lin ...
  • . Nuorani M. Encyclopedia of Medicine. Volume III Tehran: Miras ...
  • . Papageorgiou VP, Assimopoulou AN, Couladouros EA, Hepworth D, Nicolaou ...
  • . You YJ, Kim Y, Song GY, Ahn BZ. (E)-۶-(۱-alkyloxyiminoalkyl)-۵, ...
  • . Singh B, Sharma M, Meghwal P, Sahu P, Singh ...
  • . Malik S, Bhushan S, Sharma M, Ahuja PS. Biotechnological ...
  • . Liang W, Cai A, Chen G, Xi H, Wu ...
  • . Huang G, Zhao HR, Meng QQ, Zhang QJ, Dong ...
  • . Gao H, Liu L, Qu ZY, Wei FX, Wang ...
  • . Kim JS, Kim JC, Na BK, Jeong JM, Song ...
  • . Calvin SE, Oyen ML. Microstructure and mechanics of the ...
  • . Meller D, Pires RT, Mack RJ, Figueiredo F, Heiligenhaus ...
  • . Ye X, Berg M, Fossum C, Wallgren P, Blomström ...
  • . Liu T, Ma C, Yang L, Wang W, Sui ...
  • . Gatera M, Bhatt S, Ngabo F, Utamuliza M, Sibomana ...
  • . Mahbod M, Shahhoseini S, Khabazkhoob M, Beheshtnejad AH, Bakhshandeh ...
  • . Muñoz LS, Barreras P, Pardo CA. Zika virus–associated neurological ...
  • . Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus ...
  • . Glass RI, Bresee JS, Parashar UD, Jiang B, Gentsch ...
  • . Guerrant RL, Carneiro-Filho BA, Dillingham RA. Cholera, diarrhea, and ...
  • . Ruiz-Palacios GM, Pérez-Schael I, Velázquez FR, Abate H, Breuer ...
  • . Sanford C, Langley JM, Halperin SA, Zelman M, Maritime ...
  • . Lavie G, Valentine F, Levin B, Mazur Y, Gallo ...
  • . Malhotra C, Jain AK. Human Amniotic Membrane transplantation: different ...
  • . Miki T. Amnion-derived stem cells: in quest of clinical ...
  • . Kjaergaard N, Hein M, Hyttel L, Helmig R, Schønheyder ...
  • . Shimazaki J, Yang HY, Tsubota K. Amniotic Membrane transplantation ...
  • . Tehrani FA, Modaresifar K, Azizian S, Niknejad H. Induction ...
  • . Field AK, Biron KK. The end of innocerice revisited: ...
  • . Vlietinck AJ, Vanden Berghe DA. Can ethnopharmacology contribute to ...
  • . Cragg GM, Newman DJ, Snader KM. Natural products in ...
  • . David M, Peter M, Hawley. Fields Virology. New York: ...
  • . Collier L, Balows A, Sussman M. Microbiology and microbial ...
  • . Shi W, Chen M, Xie L. Amniotic membrane transplantation ...
  • . Cheng AM, Tseng SC. Self-retained amniotic membrane combined with ...
  • . Mencucci R, Paladini I, Menchini U, Gicquel JJ, Dei ...
  • نمایش کامل مراجع