Apoferritin nanocages for delivery of anticancer drug

In recent years, nanotechnology has attracted attention for its capability to diagnose and remedy diverse tumors successfully. Protein nanocarriers as a platform of targeted drug delivery can be used to reduce toxicity and improve the effect of anticancer drugs. Idarubicin (IDR) is a chemotherapy drug that is classified as an anthracycline antitumor. In this study, IDR was encapsulated within horse spleen apoferritin (HsAFr) nanocarriers. Encapsulation was obtained through disassembling apoferritin into subunits at pH ۲ and subsequently reassembling it at pH ۷.۴ in the presence of IDR. UV-vis, and fluorescence spectroscopy techniques showed that drug molecules are loaded within apoferritin. Intrinsic fluorescence information exhibited that the encapsulation does not have any effects on the tertiary structure of the protein.

کلیدواژه ها:

anticancer ، apoferritin ، breast cancer