Real-Life Toxicants as an Emerging Challenge in the Rehabilitation of COVID-۱۹ Survivors

Awareness of  COVID-۱۹ infection, as a public crisis, makes an emergency condition for survivors. Regarding the importance of early rehabilitation, we should pay particular attention to the potential risk of real-life toxicants in COVID-۱۹ survivors. The adverse effects underlying COVID-۱۹ infection lead to persistent sequelae in survivors. In addition, complete rehabilitation is challenging in seriously-ill patients due to cytokine storm severity, inflammation, oxidative stress, and cell death contributing to multi-organ damage. Different foods, environmental/occupational pollutants, and unhealthy lifestyles are real-life examples of toxicants that can pose redox imbalance and oxidative damage to the biological system. The key concept is that survived patients with persistent tissue damage, low-grade inflammation, oxidative stress, and fibrosis are susceptible to real-life toxic stressors, which have the potential for oxidative stress. Moreover, fibrosis are susceptible to toxic stressors, which can induce harmful effects by promoting oxidative stress and pro-inflammatory components. This paper attempted to elucidate a vital toxicological concept in which the existing sequelae of COVID-۱۹ survivors increase the potential risk of real-life toxicants and to propose a practical strategic approach to reduce toxicant exposure. Abbreviation: Lipid radical (L•), Lipid peroxyl radical (LOO•), Lipid alkoxyl radical (LO•), particulate matter (PM), reactive oxygen species (ROS), ultra-fine particle (UFP).

کلیدواژه ها:

Toxicant ، COVID-۱۹ survivor ، Oxidative stress ، Risk management