Polymer Modified Carbon Paste Electrode as a Sensitive Sensor for the Electrochemical Determination of Riboflavin and Its Application in Pharmaceutical and Biological Samples

Poly (threonine) modified carbon paste electrode (PTMCPE) can be used as a responsive and selective electrocatalytic sensor for the estimation of riboflavin (RF) by means of cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The proposed electrode creates a catalytic enhancement in redox behavior of RF when equated with bare carbon paste electrode (BCPE). Under optimized conditions, RF quantification at modified electrode has shown a detection limit of ۱.۷۸×۱۰-۷ M in the linear range of ۰.۲-۱ µM and ۱-۵ µM. Simultaneous analysis of RF with folic acid (FA) and ascorbic acid (AA) shows well-separated peaks leading to a quick and selective analysis of RF. The fabricated sensor can be successfully applied to RF analysis in human blood serum and B- complex tablet with acceptable results. Simultaneous analysis of RF with folic acid (FA) and ascorbic acid (AA) shows well-separated peaks leading to a quick and selective analysis of RF. The fabricated sensor can be successfully applied to RF analysis in human blood serum and B- complex tablet with acceptable results.

کلیدواژه ها:

Riboflavin ، Electrochemical sensor ، Carbon paste electrode ، Poly (threonine) ، Ascorbic acid ، Folic acid