Construction of a New Electrochemical Sensor Based on MoS۲ Nanosheets Modified Graphite Screen Printed Electrode for Simultaneous Determination of Diclofenac and Morphine

This study used a hydrothermal method to synthesize MoS۲ nanosheets (NSs). The study also utilized various analytical procedures to characterize the MoS۲ NSs. It has been found that XRD, in particular, gave information on the crystal structure of the MoS۲ NSs. These NSs have been visible with SEM. In addition, EDX has been used to scrutinize MoS۲ NSs formation. Moreover, MoS۲ NSs modified graphite screen printed electrode (MoS۲ NSS/GSPE) has been built by dropping the MoS۲ NSS onto GSPE for making a voltammetric sensor as well as the evaluation of the morphine voltammetric behavior. Findings showed stronger electro-catalytic oxidation of MoS۲ NSS for morphine with a more negative potential. Consequently, the modified electrode enabled the simultaneous detection of diclofenac and morphine with the peak potential at ۰.۴۷ V and ۰.۲۷ V. Results indicated linear response in a concentration range between ۰.۰۵ and ۶۰۰.۰ μM (morphine) with ۰.۰۳ μM limit of detection (LOD). Finally, the modified electrode has been substantially utilized for analyzing diclofenac and morphine in the samples of diclophenac tablet, urine, and morphine ampoule with acceptable recovery and accuracy.

کلیدواژه ها:

Diclofenac ، Graphite screen printed electrode ، Morphine ، MoS۲ nanosheets