Introduction: In December ۲۰۱۹, a new coronavirus strain called SARS-COV-۲ represented a significant challenge for general wellbeing. The Virus can cause mental disability, particularly memory, through the brain parenchyma deterioration and glucose metabolism impairment. Also, elderly persistent home quarantine to prevent the disease, affects their mental condition adversely. Since elders are the most vulnerable group to
Covid-۱۹ and there are almost ۵۰ million individuals with Alzheimer's around the world, this review expects to analyze the most recent in Alzheimer's disease and
Covid-۱۹ in older adults.
Methods: By searching the databases; SID, IranDoc, Google scholar, PubMed, Medline, Scopus, Cochrane Library, Science Direct and using the keywords "Elder", "Covid-۱۹", "Corona virus" and "Alzheimer"; all articles examining association between
Covid-۱۹ disease and
Alzheimer were
included in the study. Electronic search was performed during ۲۰۱۹-۲۰۲۱.
Results: Findings of ۱۸ selected studies showed; there is a reasonable connection between these two disease which can be proven in both biological and behavioral dimensions. Likewise, cognitive impairment, irritability, mood and communication disorders in the elderly with and without Alzheimer's disease occurred with a steep slope during the
Covid-۱۹ quarantine contrasted with the time before the pandemic.
Conclusions: Considering the known pathophysiological connection between these two diseases, the decrease of social and physical activities during isolation and particularly relatives' partition, leads to a decrease in sensory stimulation and increased loneliness in the elderly and also cause restlessness,
cognitive disorders and hallucinations in these people. Although limitations are important to combat the
Covid-۱۹ outbreak, it is vital for meet seniors' mental requirements, particularly those with Alzheimer's disease, and their families, and appropriate estimates should be taken to assist them with
enduring the pandemic.