Prevalence of Squamous and Basal Cell Carcinomas in African Albino Skin Cancers: A Systematic Review and Meta-analysis of Proportion

Introduction: Keratinocyte carcinomas are the most common malignant conditions in Caucasian populations. African albinos have hypomelanized sensitive skin that is quite susceptible to photo carcinogenesis. Of the keratinocyte carcinomas, Squamous Cell Carcinoma (SCC) has been found more frequent in pigmented Africans, while Basal Cell Carcinoma (BCC) predominates in Caucasians. The aim of the present study was to estimate the prevalence of cutaneous SCC and BCC in all histologically confirmed skin cancer lesions in African albinos.Data Source: Five databases: African journals on line (AJOL), PUBMED, Europe PMC, Google scholar, and Cochrane librarywere searched for relevant articles.Study Selection: Included studies were case series and cross sectional studies of histologically confirmed skin cancers in African albinos. Data extraction and synthesis was informed by Meta-analysis of Observational Studies in Epidemiology Guideline. By random effect meta-analysis, we calculated the pooled prevalence of SCC and BCC in skin cancer lesions of the African albino.Results: We abstracted ۶۹۵ skin cancer lesions from ۵۴۰ African albinos (۲۷۵ male and ۲۴۱ female albinos with sex not stated in ۲۴ subjects). There were ۴۱۹ SCCs and ۲۴۹ BCCs. By meta-analysis, the pooled prevalence of SCC was ۶۴% (۹۵% CI: ۵۰- ۷۷%). In addition, the prevalence for BCC was ۳۱% (۹۵% CI: ۱۹-۴۵%).Conclusion: Squamous cell carcinoma is the predominant type of keratinocyte carcinoma reported in African albinos.

کلیدواژه ها:

Keratinocyte Carcinoma ، African Albino ، Squamous Cell Carcinoma ، Basal cell carcinoma ، Skin Cancer