Neuromodulatory effects of anti-diabetes medications: A mechanistic review
محل انتشار: هفتمین همایش سالیانه دانشگاه علوم پزشکی سمنان
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 68
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شناسه ملی سند علمی:
CSUMSMED07_223
تاریخ نمایه سازی: 20 دی 1401
چکیده مقاله:
Diabetes mellitus is a potent upstream event in the molecular pathophysiology which gives rise to various diabetes-related complications. There are several classes of anti-diabetic medications that have been developed to normalize blood glucose concentrations through a variety of molecular mechanisms. Beyond glucose-lowering effects, these agents may also provide further therapeutic potential. For instance, there is a high incidence of diabetes-induced neuronal disorders among patients with diabetes, who may also develop neurodegenerative and psychological complications. If anti-diabetic agents can modify the molecular mechanisms involved in the pathophysiology of neuronal comorbidities, this could potentially be translated to reducing the risk of other neurological conditions such as Alzheimer’s disease, Parkinson’s disease, depression, memory deficits and cognition impairments among patients with diabetes. This review aimed to shed light on some of the potentially beneficial aspects of anti-diabetic agents in lowering the risk or treating neuronal disorders by reviewing the molecular mechanisms by which these agents can potentially modulate neuronal behaviors.
کلیدواژه ها:
نویسندگان
Habib Yaribeigi
Semnan University of Medical Sciences, Semnan, Iran
amirhossein Sahebkar
Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
Mohammad Amin Hemati
Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran