The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial

Abstract Background: Endometrial receptivity is crucial for embryo implantation, and excessive uterine contraction reduces success. Nifedipine which is a calcium channel blocker, could decrease uterine contraction and improve pregnancy outcomes. Objective: This study aimed to assess the effect of Nifedipine before embryo transfer on the pregnancy outcome in women undergoing in vitro fertilization (IVF) in a tertiary center in Iran. Materials and Methods: ۱۵۰ women who were candidates for IVF were randomly assigned into ۲ groups: group ۱ received ۲۰ mg Nifedipine ۳۰ min before embryo transfer, and group ۲ received no intervention. Blood pressure of the participants was monitored every ۱۰ min for ۱ hr under the supervision of an anesthesiologist. Finally, implantation rate and chemical and clinical pregnancy rates were compared between groups. Results: At the end of the study, ۱۴۰ participants were included in the final analyses. No significant difference was observed in clinical pregnancy rates between groups (۲۰% vs. ۲۲%, p = ۰.۵۱) Conclusion: Nifedipine administration before embryo transfer does not improve the implantation and clinical pregnancy rates in women undergoing IVF.

کلیدواژه ها:

Nifedipine ، In vitro fertilization ، Uterus ، Contraction. ، نیفدیپین ، لقاح خارج رحمی ، رحم ، انقباض.