The Protective Effect of Hydroalcoholic Extract of Green Tea (Camellia sinensis L.) on Anxiety Behaviors Induced with Chronic Noise Stress in Adult Male Wistar Rats
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137
فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JKMU-26-4_003
تاریخ نمایه سازی: 19 دی 1401
چکیده مقاله:
Background: The recruitment of medicinal herbs for the treatment of psychological disorders such as anxiety and stress has a long history. The purpose of the present study was to investigate the compensatory effects of hydroalcoholic extract of green tea on anxiety behaviors that are induced by noise stress in male Wistar rats. Methods: In this study, male Wistar rats weighing ۲۰۰±۲۰ g were randomly divided into six groups (n = ۱۰): ۱) control group, ۲) sham- noise stress (two times per day and each time for ۱۵ minutes, for ۲۱ days, without noise stress), ۳) chronic noise stress (two times per day and each time for ۱۵ minutes, for ۲۱ days, at ۸۷.۳ dB(A) and the frequency of ۸۰ kHz), ۴) Green tea (۵۰, ۱۰۰, ۱۵۰ mg/kg i.p. for three weeks), ۵) sham- green tea with saline injection for ۲۱ days, ۶) noise stress + green tea extract (۵۰, ۱۰۰, ۱۵۰ mg/kg i.p. for three weeks). Their serum cortisol levels was measured by ELISA test before and after the tests. Behavioral tests were performed including elevated plus-maze, territory discrimination, and passive avoidance test. All statistical analyses were performed using SPSS software. Results: Serum corticosterone levels significantly decreased in noise stress groups treated with green tea compared to the control group (p <۰.۰۵). Based on the passive avoidance test, the time spent in the dark box showed a significant decrease in the noise stress group treated with green tea (۱۵۰ mg/kg) compared to the noise stress group. Based on the territory discrimination test, the delay for entering the foreign segment in the green tea treated-groups showed a significant decrease (p <۰.۰۵) as compared to the noise stress group. The results of the elevated plus-maze test showed a significant increase in the time spent on the open arms in green tea extract-treated groups in comparison with noise stress group. Conclusion: Findings show the unique properties of green tea extracts in reducing serum corticosterone levels and improvement of anxiety behaviors caused by noise stress in animals. In addition, the useful effects of herbal medicine on anxiety disorders were confirmed in our study.
کلیدواژه ها:
نویسندگان
Mohammad Hossein Mohammadi Mahdiabadi Hasani
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Fatemeh Masjedi
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Farnaz Khadivi
Department of Anatomical Sciences, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
shima mohammadi
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :