Circulating Levels of C۱q/TNF-Related Protein-۱۲ (CTRP-۱۲) in Patients with Type ۲ Diabetes: A Case-control Study

Background: The C۱q complement/TNF-related protein (CTRP) superfamily is a newly diagnosed adipokine with anti-inflammatory, insulin sensitivity, and glucose lowering effects. This study aimed to assess the plasma circulating levels of CTRP۱۲ in type ۲ diabetic (T۲D) patients and healthy subjects. Methods: In this case-control study, plasma concentration of CTRP۱۲ was measured by ELISA in ۶۰ subjects (۳۰ T۲D and ۳۰ healthy participants). The systolic blood pressure (SBP), waist circumference (WC), waist-to-hip ratio (WHR), body mass index (BMI), fasting blood sugar (FBS), glycated hemoglobin (HbA۱c), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were measured. Results:In contrast to the SBP, WC, WHR, BMI, FBS, HbA۱c, insulin, and HOMA-IR, the levels of CTRP۱۲ were significantly lower in T۲D patients. There was significant negative correlation between CTRP۱۲, FBS, and HbA۱c. The regression analysis showed that when subjected to stepwise multiple regression analysis, HbA۱c (β = -۲.۲۱; P < ۰.۰۰۴) was predictive of plasma levels of CTRP۱۲. Conclusion: Finally, HbA۱c was predictive of CTRP۱۲ levels. It seems that CTRP۱۲ could be considered as a novel biomarker for the prediction of T۲D.

کلیدواژه ها:

Type ۲ diabetes CTRP ، ۱۲ Adipolin