Comparison of Serum Changes of Interleukin-۱۷A and Interleukin-۲۱ Between Schizophrenic Patients and Healthy Individuals

Background: Immunological alterations in schizophrenic patients have been considered during last decade. There are no remarkable reports on the changes of IL-۱۷A and IL-۲۱ in schizophrenic patients. Therefore, the purpose of this study was to evaluate changes of serum IL-۱۷A and IL-۲۱ in schizophrenic patients in comparison with healthy controls. Methods: In the present study serum levels of IL-۱۷A and IL-۲۱ in ۳۰ patients with schizophrenia before treatment and three months after treatment were measured by enzyme-linked immunosorbent assay (ELISA) and compare to ۳۰ match healthy control group. Results: Serum levels of IL-۲۱ in schizophrenic patient was significantly higher than control group (P= ۰.۰۰۱). Serum levels of IL-۱۷A in the schizophrenic patients had no significant changes than the control group (P= ۰.۴). Serum levels of IL-۱۷A in patients with schizophrenia three months after treatment than before treatment had no significant change (P=۰.۷) and IL-۲۱ serum levels in schizophrenic patient three month after treatment was not significant changed in comparison with this group before treatment (P= ۰.۰۶). Conclusions: The serum levels of interlukine-۲۱ is elevated in schizophrenic. Results of this study showed that IL-۲۱ might be involved in the pathologic mechanism of schizophrenia.

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Keywords: Immunity ، Interleukin-۱۷A ، Interleukin-۲۱ ، Schizophrenia.