Vitamin D and Female Infertility: New Evidence

Background: Vitamin D plays an important role in fertility andinfertility concepts. Several pathogenetic mechanisms may beproposed as a linkage between vitamin D deficiency and infertility.The purpose of this review is to provide up-to-date evidenceregarding the impact of vitamin D on female infertility.Materials and Methods: “Vitamin D, fertility and infertility”terms was searched on Pubmed for English language publicationsfrom ۲۰۱۵ up to May ۲۰۲۱. There are a large number of invitro, animal as well as human observational s tudies which arelooking at an association between vitamin D and female fertility.Jus t ۲۰ mos t recent s tudies were included in this review.Results: Mos t of the s tudies sugges t that vitamin D might havebeneficial effects on metabolic/hormonal parameters of PCOSand endometriosis, however the cause-effect relationship hasnot yet been es tablished. Also, it has been shown that vitaminD is involved in the modulation of the reproductive process inwomen due to the expression of vitamin D receptor (VDR) and۱α-hydroxylase in reproductive tissues such as ovary, uterus,placenta, pituitary and hypothalamus.Conclusion: These findings s trongly show that Vitamin D is akey role in female fertility and therapeutic approach to use itin combination with other infertility treatments can be beneficial.To determine the exact role of vitamin D in female infertility,Large-scale, high quality s tudies with longer follow-up areneeded.

کلیدواژه ها:

Fertility ، Infertility ، Vitamin D Receptor