Nutrigenomics: Future Prospect of Personalized Assisted Reproductive Technology S trategiesBinaafar S

Background: Following birth of Louise Brown in ۱۹۷۸, healthworld observed a great success of assis ted human reproductivetechnology (ART) progresses. Although, what was discovered,is the tip of the iceberg Infertility is a major reproductive healthproblem, with ۴۰−۵۰% of cases having a male factor component.Current data provide that male obesity negatively influencesmale fertility potential. There is now a provided proof that obesity in men impairs children's metabolic and reproductivehealth. At the firs t glance, these are seemed bidirectionalterms that are interrelated as two sides of a coin.Materials and Methods: Metformin therapy considered as thefirs t line of treatment of obesity. Recently, it has been reportedsome contradictory findings on that this drug can act in differentorgans and tissues including the male reproductive sys tem.Furthermore, it is well es tablished that spermatogenesis is a dynamicand multis tep process of male germ cell proliferation anddifferentiation.Results: Today, there are increased evidence of a direct link betweengenome/ epigenome and diet that makes one of the mos timportant emerging areas of medical science. Nutrigenomicsrepresents a cons tellation of unders tanding of genetics, omictechnologies and nutrition. It has the potential to shift towardsindividual genetic makeup. The world has tas ted its sweetnessin the illnesses like phenylketonuria and lactose intolerance. As trong s tep to pass selecting individual dietary components.Conclusion: There are great expectations for nutrigenetics, especiallyin regard to effect of diet on the epigenetic modulationof gene expression. The specific field that is proposed on thepremise a more useful approach. This exciting area of interactionbetween genotype and diet that may illus trate differents trategies of reproductive health. Today, we mus t pass “one sizefits all” model and enter to “personalized nutrition” way and donot forget “caution”. Also, we mus t not ignore pharmacogeneticsapproaches in the ART clinical practice.

کلیدواژه ها:

Male infertility ، Nutrigenetics ، Metformin therapy ، Obesity ، Pharmacogenetics