Aptamer base nanobiosensor for stress hormone measurement

Cortisol plays an important part in the physiological procedures. Observing cortisol concentration as a stress indicator demonstrates physiological mode for diagnosis goal. The mechanism of presented nanobiosensor is LSPR and performed based on the nucleic acid aptamer functionalized with gold nanoparticles which has specific interaction with cortisol. The interaction of aptamer particular measurement of cortisol was accomplished over the concentration from ۰.۰۵ -۰.۲ µg·mL-۱ within ۲۰ minutes. The detection limit is estimated to be ۰.۰۲ µg.mL-۱.

کلیدواژه ها:

Aptamer ، Silver Nanoparticles ، Nanobiosensor ، cortisol