The effect All-trans retinoic acid on ovarian follicle development inN-MRI mice

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 162

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شناسه ملی سند علمی:

BSCONF09_197

تاریخ نمایه سازی: 19 آذر 1401

چکیده مقاله:

Background: Vitamin A (retinol) important for normal growth, vision,reproduction,maintenance of numerous tissues, and overall survival in many species. Objective: In thepresent study the effects of retinoic acid was investigated on Mouse Ovary. Materials andMethods: In this study, newborn female NMRI were injected intraperitoneally with all-transretinoic acid ۲۵ mg/Kg.b.w was dissolved in ۲.۵% DMSO on the day of birth. After ۲۱ dayfemale mice were isolated. They were sacrificd by cervical dislocation at ۶۰ day. The ovariesfrom both groups were fixed and then were used for histological studies. The excised ovariesfrom both groups were weighed. Results:Our results indicate that retinoic acid significantlyincreased the percentage of antral follicles and corpus loteum .Retinoic acid alsosignificantly increased ovary weight (P < ۰.۰۵). Conclusions:According to our findingsretinoic acid can be improve ovulation by positive effect on folliculogenesis.

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نویسندگان

Amin Abdi

Faculty of Basic Sciences, Razi University, Kermanshah, Iran

Mehri Azadbakht

Professor of Faculty of Basic Sciences, Razi University, Kermanshah

Elahe solimani

Bachelor of Applied Science ,Cultural Management at the University of Ilam