Asymmetric synthesis of amines: reductive amination of carbonyl compounds with reductive aminases

Chiral primary amines are essential components of the manufacturing process for variouspharmaceutical medicines. Reductive aminases and imine reductases belong to the samefamily of enzymes, although the latter are specialized to catalyze the reduction of preexistingcyclic imines. Imine reductases have a subtype termed reductive aminases for furtherbreakdown. However, reductive aminases also reduce preexisting cyclic imines in addition tocatalyzing the reductive amination between carbonyl substrates and amine nucleophiles.Since amines can be produced via multiple metabolic routes, the potential for the directreductive amination of ketone substrates by enzymes has just recently been investigated. Thisapproach could be particularly advantageous because it would eliminate the need for asubstrate to be chemically created before a reduction could occur, as imine could be producedon-site. This paper researched to find clues about the enantioselectivity of different reductiveaminase enzymes and considered some aspects, including absolute configurations, type ofenzymes, their sources, and synthesized products.

کلیدواژه ها:

Chiral amines ، Asymmetric synthesis ، Reductive amination ، Reductive aminase