Synthesis and characterization of chitosan nanoparticles loaded with ascorbicacid as drug delivery system

Ascorbic acid, which is known as vitamin C, has various biological, medicinal and skin functions. Ascorbic acid isvery unstable against air, light, heat, moisture, metal ions, oxygen and base and easily decomposes into inactivebiological compounds. Chitosan is a highly biodegradable, bioavailable and non-toxic polymer that has very importantmedicinal properties Nanocarriers play an important role in increasing shelf life, bioavailability, bioactivity andreducing drug toxicity. This research was done with the aim of synthesizing chitosan nanoparticles. Chitosan wasreacted with sodium tripolyphosphate (STPP) to prepare nanoparticles containing vitamin C. The drug entrapmentefficiency (EE) and loading efficiency (LE) were determined using UV-visible spectroscopy were reached up to ۸۶.۶% and ۸.۶۹%, respectively. In vitro release studies showed a sustained release of ascorbic acid from chitosannanoparticles.

کلیدواژه ها:

ascorbic acid ، chitosan ، nanoparticles ، sustained release