Highly porous bio-glass scaffolds fabricated by polyurethane template method with hydrothermal treatment for tissue engineering uses
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 12
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 315
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شناسه ملی سند علمی:
JR_IJBMS-25-12_013
تاریخ نمایه سازی: 25 آبان 1401
چکیده مقاله:
Objective(s): Bioglass scaffolds, which contain a significant percentage of porosity for tissue engineering purposes, have low strength. For increasing the strength and efficiency of such structures for use in tissue engineering, fabrication of hierarchical meso/macro-porous bioglass scaffolds, developing their mechanical strength by hydrothermal treatment and adjusting pH method, and achieving the appropriate mesopore size for loading large biomolecules, were considered in this study.Materials and Methods: Mesoporous bioglass (MBG) powders were synthesized using cetyltrimethylammonium bromide as a surfactant, with different amounts of calcium sources to obtain the appropriate size of the mesoporous scaffolds. Then MBG scaffolds were fabricated by a polyurethane foam templating method, and for increasing scaffold strength hydrothermal treatment (۹۰ °C, for ۵ days) and adjustment pH (pH=۹) method was used to obtain hierarchical meso/macro-porous structures. The sample characterization was done by Simultaneous thermal analysis, Fourier transform infrared spectroscopy, Field Emission Scanning electron microscopy, small and wide-angle X-ray powder diffractions, transmission electron microscopy, and analysis of nitrogen adsorption-desorption isotherm. The mechanical strength of scaffolds was also determined.Results: The MBG scaffolds based on ۸۰.۲۸ (wt.) % SiO۲- ۱۷.۸۹ (wt.) % CaO- ۱.۸۱ (wt.) % P۲O۵ presented interconnected large pores and pores in the range of ۱۰۰-۱۵۰ μm and ۶-۱۸ nm, respectively and ۰.۴ MPa compressive strength. Conclusion: The total pore volume and specific surface area were obtained from the Brunauer-Emmett-Teller theory, ۰.۷۰۹ cm۳ g-۱ and ۲۱۳.۸۳ m۲ g-۱, respectively. These findings could be considered in bone-cartilage tissue engineering.
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نویسندگان
Maryam Badiee
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran ۱۴۷۷۸-۹۳۸۸۵, Iran
Nahid Hassanzadeh Nemati
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran ۱۴۷۷۸-۹۳۸۸۵, Iran
Mohammad Taghi Khorasani
Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran ۱۴۹۷۷-۱۳۱۱۵, Iran
Mohammad Ali Shokrgozar
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran ۱۳۱۶۹۴۳۵۵۱, Iran
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