The Immunologic Basis of COVID-۱۹: a Clinical Approach

The novel severe acute respiratory syndrome coronavirus (SARS-CoV۲) has leaded to a global infection and a pandemic afterwards. This pandemic is one of the greatest global challenges for the health system. In this review, the immunologic basis of the human body response after infection with SARS-CoV۲ has been reviewed with discussions on both innate and adaptive immunity. Due to the relatively short time after appearance of the problem, the currently available evidence exclusively dealing with SARS-CoV۲ and the disease, coronavirus diseases ۲۰۱۹ (COVID-۱۹) are scant; especially in the field of cellular and molecular medicine; however, previous studies especially focusing on SARS-CoV and MERS are available. At the final part of the manuscript, involvement of the main human organs with COVID-۱۹ is briefed.

کلیدواژه ها:

SARS-CoV۲ ، COVID-۱۹ ، immunologic response ، innate immunity ، adaptive immunity