COVID-۱۹ Severity and Comorbidities in Diabetic Patients

Background: This study aimed to investigate the demographic factors, comorbidities, and laboratory results of diabetic patients with coronavirus disease ۲۰۱۹ (COVID-۱۹) severity.Materials and Methods: This cross-sectional study enrolled ۱۷۱ diabetic patients with COVID-۱۹ admitted based on chest CT scan findings to the COVID-۱۹ ward of Shahid Mohammadi Hospital in Hormozgan, Iran from ۱ March to ۱ June, ۲۰۲۰. Reverse-transcriptase polymerase chain reaction (RT-PCR) test was performed, and the patients were divided into three groups (mild, moderate, and severe) based on the severity of disease. Then we investigated the demographic factors, comorbidities, and laboratory results of diabetic patients with severe COVID-۱۹ severity.Results: Regarding comorbidities, there was no significant difference between the three groups. Moreover, there was a significantly lower lymphocyte count in the severe group compared to moderate and mild groups (P = ۰.۰۰۱). We showed the increase in blood urea nitrogen (BUN) and creatinine to be significantly associated with increased disease severity (P = ۰.۰۰۱ and P = ۰.۰۰۹, respectively). We also showed a significant difference in aspartate aminotransferase (AST) levels between different groups of patients (P = ۰.۰۰۲) with a higher level of AST in the severe group (P = ۰.۰۲۰). Lactate dehydrogenase (LDH) and troponin were also significantly associated with an increase in COVID-۱۹ severity in patients with diabetes (P = ۰.۰۱۳ and P = ۰.۰۰۲, respectively).Conclusion: There was a significant association between disease severity and BUN, creatinine, AST, LDH, and troponin levels in diabetic patients with COVID-۱۹. There was no significant association between different groups regarding severity of disease and comorbidities.

کلیدواژه ها:

Diabetes mellitus ، COVID-۱۹ ، Severity ، Laboratory findings