Applications of Bacillus as probiotics for human use

Background and Aim : The use of Bacterial spore formers such as Bacillus spp. in probioticsupplements and foods has increased considerably over the last decade. Bacillus species have beenused as probiotics for at least ۵۰ years with the Italian product known as Enterogermina. Sporesof Bacillus spp. are heat-resistant and capable of surviving the low pH of the gastric barrier whileactive probiotics as Lactobacillus are susceptible to bile salts and gastric acid. Therefore, Bacillusspp. are a good choice for use as probiotics.Methods : In this study, we searched for papers and book in electronic databases (PubMed,Medline, Google scholar, Web of Science, Scopus) using keywords such as: Bacillus, probioticsupplements, spore and commercial probiotics from their inception up to ۲۰۲۲.Results : The stability during processing and storage, ease of production and therapeutic potentialsuch as antimicrobial activities, prevent gastrointestinal disorders and immune stimulation makeBacillus spp. a suitable candidate for commercial manufacture of novel foods and supplements forhuman and animal feeds. Bio-KultR B. subtilis; ThorneR: Bacillus coagulans; BiosporinR; B.subtilis ۲۳۳۵ and B. licheniformis ۲۳۳۶ and MegaSporeBioticTM; B. licheniformis, Bacillusindicus, B. subtilis, B. clausii and Bacillus coagulans, are only part of probiotic supplementscontaining Bacillus strains in global market for human use.Conclusion : Today, Bacillus spp. spores are being used extensively in dietary supplements asprobiotics. Bacillus spp. which have GRAS status from the FDA and are included in the QPS, usedas probiotics for human and animal hosts and only a few are ordinarily used as probiotics, theseinclude Bacillus coagulans, B. clausii, B. licheniformis, B.cereus and B. subtilis.

کلیدواژه ها:

Bacillus ، probiotic supplements ، spore ، commercial probiotics