Mycoplasma pneumoniae infection among children: asystematic review and meta-analysis

Background and Aim : Mycoplasma pneumoniae (M. pneumoniae) is a common cause ofcommunity-acquired pneumonia in children and adolescents, which can be fatal in certain cases.Identifying the incidence and severity of this infection in individuals under the age of ۱۸ can assistto improve the treatment and prevention process. In the present study, we aimed to evaluate thefrequency of M. pneumoniae infection in young patients.Methods : Three major databases, including Medline (via PubMed), EMBASE, and the Web ofScience, were carefully searched and reviewed for original research articles available in databasesand published between ۲۰۰۰ to ۲۰۲۰. STATA (version۱۴) software was used to interpret the data.Results : Of the ۴۵۱۵ records selected from the databases, ۷۷ studies fulfilled the eligibility criteriato evaluate the prevalence of M. pneumoniae infection among children. The analyses revealed thatthe prevalence of this infection in young patients was ۲۲.۵%. Our analysis based on published datashowed that ۱۰ to ۱۸ years age group had the highest prevalence of the M. pneumoniae equal to۲۳.۱% [(۹۵% CI) ۶.۷-۳۹.۴], followed by ۵ to ۱۰ years age group with ۲۱.۶% [(۹۵% CI) ۱۷.۹-۲۵.۳],and under ۵ years age group with ۲۰.۹% [(۹۵% CI) ۱۶.۷-۲۵.۱].Conclusion : It is reasonable to conclude, based on the findings of this study that the rate of M.pneumoniae infection has been increasing since ۲۰۰۱. Finally, more extensive studies on theprevalence of M. pneumoniae infections in children throughout the world are needed to assess itsexact prevalence and antibiotic resistance trend.

کلیدواژه ها:

Mycoplasma pneumoniae ، Children ، Infection ، Meta-analysis