Investigating the antibacterial and healing effect of medicinalplant extracts along with silver sulfadiazine in the treatment of burninfection

Background and Aim : In the present study, extracts were first prepared from yarrow, marigold,Arnebia euchroma L and castor oil plants. Then, to determine the MIC (minimum inhibitoryconcentration) and MBC (minimum lethal concentration) dilution method in broth or microdilutionwas used. Then, to check the synergistic effects of the extracts, dilution in broth was done for eachextract separately. Then, the prepared ointment was tested on an animal model that was infectedwith Staphylococcus aureus and Pseudomonas aeruginosa bacteria.Methods : In the present study, extracts were first prepared from yarrow, marigold, Arnebiaeuchroma L and castor oil plants. Then, to determine the MIC (minimum inhibitory concentration)and MBC (minimum lethal concentration) dilution method in broth or microdilution was used.Then, to check the synergistic effects of the extracts, dilution in broth was done for each extractseparately. Then, the prepared ointment was tested on an animal model that was infected withStaphylococcus aureus and Pseudomonas aeruginosa bacteria.Results : The results of the study indicate that: aqueous and ethanolic plant extracts extracted fromArnebia euchroma L, marigold, castor oil and yarrow caused better and faster healing in burnwounds than the antibiotic silver sulfadiazine in ratsConclusion : According to the findings of this study, it can be concluded that the extracts of thesefour plants together with the antibiotic silversulfadiazidin on an animal model have anantimicrobial effect against Staphylococcus aureus and Pseudomonas aerogenza bacteria and havea healing effect on wound infection caused by burns. They can be considered as an antibacterialsubstance or ointment

کلیدواژه ها:

Staphylococcus Aureus ، Pseudomonas aeruginosa ، Arnebia euchroma L ، marigold ، castor oil ، yarrow ، burns