Detection of porphyromonas gingivalis DNA in the synovialfluid of rheumatoid arthritis patients bt real-time PCR

Background and Aim : microbial infections are believed to play an important role in the initiationand prepetuation of rheumatoid arthritis.This study aimed to investigate the relationship betweenthe presence of Porphyromonas gingivalis DNA in the synovial fluid and rheumatoid arthritis.Methods : the synovial fluid sample wew collected from ۲۲ patient whith rheumatoid arthritiesand ۲۰ patient whith no suffering from rheumatism , overall ۴۲ patient were investigated. Thepresence of P. gingivalis DNA was evaluated by the real-time PCR method.Results : There was a significant relationship between rheumatoid arthritis and non-rheumatoidarthritis whith the DNA number (Pv<۰.۰۵). P. gingivalis DNA were detected in ۳ of ۲۰ (۱۳.۶%)rheumatoid arthritis patients, but there was no significantrelationship between P. gingivali DNAand rheumatoid arthritis (Pv>۰.۰۵).Conclusion : DNA of peridontal pathogens can be found in the synovial fluid of rheumatoidarthritis patients.It shows oral bacteria may play a role in the pathogenesis of rheumatoid arthritis.

کلیدواژه ها:

Porphyromonas gingivalis ، Synovial fluid ، Rheumatoid arthritis ، Real-time.