A review of the antifungal effects of Zataria multiflora as apossible candidate in the treatment of secondary fungal infections inpatients with COVID-۱۹

Background and Aim : Secondary fungal infections are one of the most important causes of deathin patients with COVID-۱۹, and among these fungi, we can mention Candida, Aspergillus, andMucorales strains, which respectively cause candidemia, pulmonary invasive Aspergillus, andmucormycosis in these patients. Therefore, increasing the acquired resistance of these fungi toantifungal compounds has made the use of alternative compounds necessary, especially medicinalplants. Thus, the aim of this study is to review the antifungal effects of Zataria Multiflora as apossible candidate in the treatment of secondary fungal infections in patients with COVID-۱۹.Methods : The present study is a review study by searching in reliable scientific databasesincluding Pubmed, Google Scholar, Scopus and Web of Science from ۲۰۰۰ to ۲۰۲۲ using thekeywords: SARS-CoV-۲, COCID-۱۹, Treatment, Zataria multiflora and Aspergillus spp,Mucormycosis , Antifungal, Candida spp. Latest information obtained.Results : In this study, ۸۰ articles were reviewed. The plant Zataria multiflora belongs to the genusZataria and has effective antifungal compounds including thymol, carvacrol and parsimol. Thesecompounds showed effective antifungal effects with high inhibitory effects and lethality againstCandida albicans, Candida glabrata and Candida tropicalis, Aspergillus fumigatus, flavus, nigerand mucoral strains, and the results of these studies confirmed the antifungal effects of this plantby in vivo, invitro and clinical trials plant.Conclusion : Considering the prevalence of COVID-۱۹ disease, one of the importantcomplications of this disease is the secondary bacterial and fungal infections seen in ICU patientsand immunosuppressive patients, which can cause biofilm, shock and sepsis, respiratory distress,eye, nose, and brain infections and high mortality in patients with COVID-۱۹. Considering theeffective antifungal substances of thymol, carvacrol in the mentioned plant, and the resistance offungi to antifungal compounds, this plant can be used to be evaluated in COVID-۱۹patients withsecondary fungal infections with Candida, Aspergillus, and Mucorales. and other fungal infections.

کلیدواژه ها:

Zataria multiflora ، Antifungal ، COVID-۱۹ ، Treatment