Bacterial etiology and antibiotic resistance pattern ofbacteremia in patients with hematologic malignancies admitted to ImamReza Hospital, Mashhad: an ۸-year retrospective study

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 119

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شناسه ملی سند علمی:

MEDISM23_323

تاریخ نمایه سازی: 16 مهر 1401

چکیده مقاله:

Background and Aim : Identification of disease causing organisms, and their antimicrobialresistance patterns, is essential for appropriate empiric therapy. Patients afflicted with a variety ofhematologic malignancies are especially at risk of infection with drug resistant organisms, owingin part to recurrent infections and repeated courses of antibiotics therapy. This study aims toinvestigate the bacterial etiology and antibiotic resistance patterns of organisms isolated from theblood of bacteremic patients admitted to the Hematology and Oncology ward of Imam RezaHospital, Mashhad.Methods : In this retrospective cross-sectional study, we reviewed the medical records of allpatients admitted to the Hematology and Oncology ward of Imam Reza Hospital from March ۲۰۱۰to March ۲۰۱۷, for whom at least one positive blood culture was recorded. Obtained data includeddemographic information, blood culture and antibiogram results, and outcome.Results : A total of ۱۰۷ patients were included (mean age ۴۳.۸±۱.۸). ۶۰ (۵۶%) were male, and ۴۷(۴۴%) were female. The organisms most commonly isolated from the blood were, in order,Staphylococcus aureus (۱۵.۹%), Acinetobacter (۱۵%), Enterococcus (۱۳.۱%), and Staphylococcusepidermidis (۱۲.۱۹%). ۶۸ (۶۳.۵%) patients survived the episode of bacteremia, while ۳۹ (۳۶.۴۴%)died. The highest rates of antimicrobial susceptibility were seen in S. epidermidis treated withvancomycin (۹۲.۳% of isolates), and S. aureus treated with vancomycin or ciprofloxacin (۸۲.۳۵%and ۵۲.۹% of isolates, respectively).Conclusion : The most common cause of bacteremia was Staphylococcus aureus, followed closelyby Acinetobacter. The results of the present study should be considered in the management ofpatients with hematologic malignancies in the region.

نویسندگان

Mahnaz Arian

Assistant Professor of Infectious Diseases and Tropical Medicine, Department of Infectious Diseases and Tropical Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Bahare Ghorbani

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Alavi

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran