Zoliflodacin: A Hope to Treat Antibiotic-Resistant Neisseriagonorrhoeae

Background and Aim : Neisseria gonorrhoeae is a gram-negative diplococcus that leads tosexually transmitted infection. N.gonorrhoeae is an obligate human pathogen that causes infectionto the mucus-secreting epithelial cells both in males and females. In ۲۰۱۷ the center for diseasecontrol and the World Health Organization published the list of global priority pathogens-۱۲ withdenting therapeutic options, including antibiotic-resistant N. gonorrhoeae.Methods : We characterized thoroughly zoliflodacin antibiotic, its clinical trials, and its effect onhuman health by using different keywords like “moxifloxacin”, “covid-۱۹”, and “clinical trials”from different data sources like Pub-Med, Google-Scholar, and Science-Direct.Results : Zoliflodacin targets antibiotic-resistant gonorrhoeae. Zoliflodacin shows a therapeuticapproach against N. gonorrhoeae. It acts by inhibiting bacterial type ۲ topoisomerase with thebinding site in bacterial gyrase. It shows promising results against N. gonorrhoeae. Zoliflodacin iseffective in treating gonococcal urogenital and rectal infection. Discussion: Antibiotic is the onlyoption to treat N. gonorrhoeae. There is no vaccine available to treat gonorrhea. The new drug,zoliflodacin, specifically targets antibiotic-resistant gonorrhea. This is giving hope to researchers.In this study, we elaborate on the discovery of zoliflodacin, its mechanism of action, the currentclinical trials, and the effectiveness of moxifloxacinConclusion : Antibiotic is the only option to treat N. gonorrhea. There is no vaccine available totreat gonorrhoeae. The new drug, zoliflodacin, specifically targets antibiotic-resistant gonorrhea.This is giving hope to researchers. In this study, we elaborate on the discovery of zoliflodacin, itsmechanism of action, the current clinical trials, and its effectiveness of zoliflodacin.

کلیدواژه ها:

Neisseria gonorrhoeae ، Zoliflodacin ، Covid-۱۹ ، Antibiotic-resistance ، Treatment