Oral Microbiota Dysbiosis as a Prognostic Biomarker forColorectal Cancer

Background and Aim : Colorectal cancer rates are growing around the world. In terms ofdiagnosis this disease is in the fourth place. In the recent years, the roles of symbiosis microbes,which live in the human body especially in the oral cavity, and their indirect role in colorectalcancer development have received much scientist’s attention. These microbes have a critical rolein metabolism and homeostasis of the body through secretion of immune molecules, signalingpathways modulators and cell cycle intermediates. Recent studies showed that oral bacteria havefound in tumor tissues in patients with diagnosed colorectal cancer.Methods : Literature reviewResults : With advance in metagenomics technology, it is possible to detect and compare moreprecisely the symbiotic microbe’s communities that live in oral and digestive tract of human.Studies showed that detection of symbiosis bacteria in the oral cavity, which could be find incolorectal tumor tissue, might be consider as a prognostic factor for further therapeutic purposes.In this review, with an eye on future applications, we intend to consider metagenomics studies inoral cavity for introducing novel prognostic biomarkers for disease detection, control andmanagement.Conclusion : Bacterial species, which have been found in tumor tissue of patients with colorectalcancer, have an equal frequency in the oral cavity. Metagenomics studies show some of theparticular bacterial species of the oral cavity such as Porphyromonas spp., Peptostreptococcus spp.,Prevotella spp., Parvimonas spp. and Gemella spp. are associated with colorectal cancerdevelopment.

کلیدواژه ها:

Oral Microbiota ، Colorectal Cancer ، Prognostic Biomarker ، Metagenomics