The challenge of treatment multi-drug resistant strains ofAcinetobacter baumannii in burn patients in Iran

Background and Aim : Acinetobacter baumannii is second cause of burn infections in Iran. Thetreatment of antibiotic resistant strains of Acinetobacter baumannii in burn patients has turned intoa challenging puzzle. Since the skin is the first defense barrier against invasion of microbes, burnpatients are prone to infect with opportunistic bacteria such as Acinetobacter baumannii due toloss of this defense barrier. It is difficult for physicians to prescribe a suitable treatment regimenfor burn patients because these patients are infected with other bacteria such as Pseudomonasaeruginosa. Carbapenems were the choice for multi-drug resistant isolates (MDR) but withemergence of carbapenem resistance strains, tigecycline and colistin were chosen as alternativedrugs against extensive-drug resistant isolates (XDR). The present study aimed to explore thechallenge of treatment MDR strains of Acinetobacter baumannii in burn patients in Iran.Methods : In this study various databases used to select articles in both Persian and Englishlanguages. Targeted databases were Google Scholar, PubMed, Scopus, Web of Science. Theapplied keywords included multi-drug resistant strains of Acinetobacter baumannii ,burn patientsand Iran.Results : In this study, all isolates were resistant to carbapenems in genotypic and phenotypicanalysis, but showed sensitivity to colistin and tigecycline and this sensitivity was much aboutcolistin.Conclusion : Our study revealed almost all isolates from burn patients were resistant tocarbapenems and the prevalence of multi-drug resistant strains of Acinetobacter baumannii isincreasing.

کلیدواژه ها:

Acinetobacter baumannii ، MDR ، XDR ، Carbapenem