Investigation of frequency and determination of drugsensitivity of Enterobacter species causing septicemia in patientshospitalized in Hajar Shahrekord Hospital, Chaharmahal and BakhtiariProvince in ۱۴۰۰

Background and Aim : Blood infections are one of the main causes of death in the world. Gramnegativebacteria, the most abundant of which are Enterobacteriaceae, are one of the mostimportant causes of septicemia. Finding septicemia-causing bacteria and investigating its drugresistance is a prerequisite for effective and rapid treatment and preventing the progression ofinfection and mortality. Therefore, the purpose of this study is to investigate the frequency anddetermine the drug sensitivity of Enterobacter species causing septicemia in patients admitted toHajar Shahrekord Hospital, Chaharmahal and Bakhtiari Province in ۱۴۰۰.Methods : In this cross-sectional-retrospective study, all blood cultures referred to the Hajarhospital laboratory from April to March ۱۴۰۰ were examined and studied. Blood cultures werecultured in the standard environments of Blood Agar, EMB, Chocolate Agar and the growth ofbacteria was checked after ۲۴ to ۴۸ hours. Based on the type of bacteria grown, antibioticsensitivity on Müller Hinton's culture medium as disk diffusion using commercial and standarddisks has been investigated. Finally, the findings were analyzed using descriptive statistics.Results : The results of this study showed that out of ۶۳۷۶ blood cultures, ۱۷۰ samples werepositive (۲.۶۶%). Meanwhile, the causative agent of septicemia in ۴۲ cases (۲۴.۷%) of the sampleswas found to be Enterobacter species and the predominant species was Enterobacter cloacae. Havebeen. Antibiogram results showed the highest sensitivity to ciprofloxacin (۹۱.۹%), amikacin(۸۴.۳۷%), Trimethoprim / Sulfamethoxazole (۸۱.۸%) and morpheme (۵۸.۸%), respectively. In thisstudy, ۸۰% drug resistance to third-generation cephalosporins such as ceftriaxone and ۷۷% tocefotaxime and ۸۳% to cefixime were shown. Also, resistance to FEP (۶۰), SAM (۸۴), TIPZ (۶۴),CAZ (۶۴), MEN (۴۱) percent were shown.Conclusion : According to the antibiotic resistance of the third-generation cephalosporins,probably the genes for treatment are increasing. Arbitrary use of these antibiotics may be one ofthe causes of resistance.

کلیدواژه ها:

septicemia ، Enterobacter ، blood culture ، drug sensitivity