Inhibitory effect of pyocyanin pigment of Pseudomonasaeruginosa on Candida albicans in vitro

Background and Aim : Background and Aim: Candida albicans as an opportunistic pathogen cancause a wide range of skin and mucosal infections. Antibiotic treatments for this fungus haveseveral side effects that cause drug resistance. In this study, the inhibitory effect of pyocyaninpigment extracted from Pseudomonas aeruginosa on the growth of Candida albicans wasinvestigated. Methods: In this experimental study, pyocyanin peptide was extracted fromPseudomonas and its effect on Candida albicans by minimum inhibitory concentration andminimum fungicidal concentration to evaluate the antifungal effects of this substance on Candidaalbicans in the laboratory. it placed. Results: By studying different concentrations of pyocyaninpigment, it was shown that Candida albicans did not grow at concentrations of ۵۰۰۰-۱۰۰۰۰-۲۰۰۰۰-۴۰۰۰۰ and in the wells after these concentrations, growth of Candida strain was observed.Conclusion: Based on the results of this study, a certain concentration of pyocyanin can have aninhibitory effect on the growth of Candida albicans and prevent its growth; Therefore, furtherexperiments are needed to investigate the composition of this substance and its wider use intherapeutic cases.Methods : Methods: In this experimental study, pyocyanin peptide was extracted fromPseudomonas and its effect on Candida albicans by disk diffusion method, minimum inhibitoryconcentration and minimum fungicidal concentration to evaluate the antifungal effects of thissubstance on Candida albicans in the laboratory.Results : Results: By studying different concentrations of pyocyanin pigment, it was shown thatCandida albicans did not grow at concentrations of ۵۰۰۰-۱۰۰۰۰-۲۰۰۰۰-۴۰۰۰۰ and in the wellsafter these concentrations, growth of Candida strain was observed.Conclusion : Conclusion: Based on the results of this study, a certain concentration of pyocyanincan have an inhibitory effect on the growth of Candida albicans and prevent its growth; Therefore,further experiments are needed to investigate the composition of this substance and its wider usein therapeutic cases.

کلیدواژه ها:

Pyocyanin ، Pseudomonas aeruginosa ، Candida albicans