Evaloation of antimicrobial resistance of bacteria isolated fromcutaneous, soft tissue and visceral abscesses

Background and Aim : Microbial agents producing abscesses in the skin, viscera and soft tissuesinclude various types of aerobic and non- aerobic bacteria. The most important are Staphylococcusaureus, streptococcus, Escherichia coli, Pseudomonas, Bacteroides and klebsiella. The maintreatment of abscess, pushing out through drainage or split abscess. After removing the necrotictissue and pus, The antibiotic should be used to treat the disease. The aim of this study was todetermine the aerosol production of abscess in skin, viscera and soft tissue and then to evaluatetheir susceptibility to different antibiotics.Methods : Specimens of bacterial isolated from skin abscesses and infections and other connectivetissue components that were identified, cultured and antibiogram into the microbiologicallaboratory of the Tabriz children center were extracted and then clinical information was obtainedfrom patients. The data included the age, sex, location of the infection ,its association with hospitalinfections (in case of suspicion of nosocomial infections) and the manner of intervention, includingaspiration,surgical drainage,or of type of antibiotic therapyResults : clinical and laboratory data of patients with skin and soft tissue admitted to Tabrizchildren’s hospital. ۱۰۰ samples of positive blood culture were selected during ۵ years and usedfor evaluation of drug resistance pattern. In this study ۵۲.۳ % of the patients were males and ۴۷.۷%were females. Of the ۱۰۰ positive culture cases ,۴۷.۷% were Staphylococcus aureus ,۸% Klebsiellaand ۸% Esherichia coli .۴۶.۶% of cases included soft tissue abscesses,۳۳% of visceral absessesand ۲۰.۵ % of skin abcesses, The results of the antibiogram showed that Staphylococcus aureusversus penicillin was ۷۹.۵% oxacillin۳۴.۱% ,amikacin ۲۶.۲% clindamycin ,۲۹.۳%erythromycin,۳۵%cefalexin,۱۲.۵% ceftizoxime and ceftriaxone ۲۲% and Vancomycine ۲.۴% areresistantConclusion : The susceptibility and resistance pattern of Staphylococcus aureus is unpredictableand multiple resistance is common .At present resistance to Vancomycin is low ,of course. Thislevel of resistance should be confirmed by more precise methods such as MIC or E testmeasurements. Obviously .the use of Vancomycine should be limited to the treatment of seriousinfectious disease and in cases of non critical infectious disease acquired by the communityAntibiotics such as cephalexin and clindamycin can still be used .In this study ,high levels ofresistance to penicillin are also evident.

کلیدواژه ها:

Microbial Resistance ، Antibiotics ، Abscess ، Soft tissue