Multidrug-resistant Pseudomonas aeruginosa from sputum ofpatients

Background and Aim : Antimicrobial resistance (AMR or AR) is the ability of a microbe to resistthe effects of medication that once could successfully treat the microbe. Pseudomonas aeruginosais a common encapsulated, Gram-negative, rod-shaped bacterium that can cause disease.Pseudomonas aeruginosa (P. aeroginosa) is one of the opportunistic pathogens, which is the maincause of prevalent hospital infections worldwideMethods : this study aims to isolate and determine antimicrobial resistances patterns ofPseudomonas aeruginosa from Patients admitted to educational hospitals at the Urmia Universityof Medical Sciences, Iran. Clinical samples from hospitalized patientsn were collected. Then,Samples were processed and identified by standard protocol. The Pseudomonas aeruginosapositive cases was tested for antibiotic resistance kl by Kirby-Bauer disc diffusion method(according to Clinical and Laboratory Standards Institute guidelinesResults : results Among culture positive patients, ۱۰۰ bacterial isolates were recovered, asPseudomonas aeruginosa. Of the Pseudomonas aeruginosa isolates, ۱۰% were from sputum, andremained cases from other body aspirates. The highest number of the resistance was the oneagainist SXT with ۱۰۰% resistance. MERO , CTR and ZOX that used just for ۱/۳ of samples had۱۰۰% resistance,too. We had more than ۶۰% resistance to all tasted antibiotics except CO .resistace to CO was very rare (۲۵%)Conclusion : P. aeruginosa is not extremely virulent in comparison with other major pathogenicbacterial species – for exampleStaphylococcus aureus and Streptococcus pyogenes – though P.aeruginosa is capable of extensive colonization, and can aggregate into enduring biofilms.[However, if a person is in a hospital or has a weakened immune system, the threat becomes verysevere. In these situations, a Pseudomonasinfection can be life-threatening.The good news is thatthese infections are treatable, especially with an early diagnosis.