Co-delivery of doxycycline and hydroxychloroquine to treatbrucellosis: an animal study

Background and Aim : Evaluation of various biochemical and immunological parameters ininfectious diseases is one of the best indicators for diagnosis and treatment process. The main goalof this project is to determine the effect of hydroxychloroquine and doxycycline loading into solidlipid-nanoparticles (DOX-HCQ-SLN) on both acute and chronic phases of brucellosis.Methods : In addition, evaluate some biochemical factors, trace elements and inflammatoryelements. Blood serum levels of Zn, Fe, Na, K, hepatic biochemical parameters (AST, ALT, ALP,TBil) were remarkably different between infected and healthy rats.Results : Vitamin D was decreased and CRP was increased in chronic and acute brucellosis.Quantitative evaluation of these mentioned parameters can be useful to diagnose brucellosis inadvance.Conclusion : Due to the good effect of the synchronized use of hydroxychloroquine anddoxycycline in the form of nanoparticles, the manipulation of these nanoparticles can help forbetter treatment and also reduction in brucellosis re-infection

کلیدواژه ها:

Brucellosis ، trace elements ، biochemical parameters ، nanoparticles