Chemical and Judgmental Examination of Niosomes or Vesiclesof Non-Ionic Surfactants

Background and Aim : ABSTRACT Niosomes or vesicles of nonionic surfactants are very smalllayered structures obtained from a mixture of nonalionic surfactants of alkyl or diakyl polyglycerolether and cholesterol and then hydration in aqueous (aqueous) medium. Today, overuse ofantibiotics in the treatment of human and animal diseases has caused the multidrug resistance ofbacteria to antibiotics. In addition, if a new type of antibiotic is used, resistance genes will beginto appear. After a period of widespread transmission to other bacteria, the spread of resistance andthe need for new antibiotics, which requires millions of dollars. Vancomycin is used to treatinfections of many gram-positive and gram-negative bacteria. Consumption of this antibiotic isvery high due to the bacterial resistance that has been created against it as well as the side effectsthat it causes in some parts of the body. Many studies have been done on antibiotics to find asolution to eliminate the toxicity caused by their long-term use.Methods : Niosome preparation methods Niosome preparation methods include: thin filmhydration, freeze-drying, reverse phase evaporation, ether injection, sonication, micro fluidization,bubble, etc., which are described below.Results : Niosomes Benefits ➢ These vesicles are water-based carriers, which increase patientsatisfaction compared to oily drug forms.Conclusion : Conclusion The aim of the study by Abdulaziz et al. in ۲۰۱۴ was to optimizenorfloxacin niosomes to increase antibacterial activity and reduce bacterial resistance. In thisstudy, Pseudomonas aeruginosa, a bacterium that forms a biofilm, was used as the test organism.Different norfloxacin niosomes were examined in vitro and in vivo for antibacterial activity incomparison with aqueous drug solution, respectively. The effect of norfloxacin niosomes onbiofilm formation was investigated

کلیدواژه ها:

Newsome ، Dialkyl polyglycerol Ether ، Antibiotic ، Vancomycin ، Bacteria