Disseminated invasive aspergillosis after liver transplantation despitegood graft function

Background and Aim : Invasive aspergillosis (IA) is one of the most serious causes of death afterliver transplantation (LT). IA is the second most common fungal infection, and its mortality rateexceeds ۸۰%.Methods : A ۳۰-year-old man presented to our hospital because of fulminant hepatitis . whounderwent liver transplantation from a deceased donor. Pretransplant screenings for donor andrecipient such as HIV, HBV, HCV, HDV, CMV, EBV, and syphilis for donor and HIV, HAV,HBV, HCV, HDV, CMV, EBV, VZV, PPD, IGRA, and syphilis for the recipient were negative.Results : Although he appeared to have good graft function, After ۵days post transplantation vitalsigns revealed a temperature of ۱۰۱.۲°F, pulse ۹۸ beats per minute, respirations ۳۰ breaths perminute, blood pressure ۱۳۷/۹۹ mm mercury, and a room air oxygen saturation of ۸۷%. Chest CTscan revealed pleural effusion and nodular lesion.Bronchoscopy &BAL revealed positivity forAspergillus PCR, and GM. Simultaneously he had skin ulcer on abdomen.Therapy was soonmodified to Voriconazole combined with caspofungin.Conclusion : The present report describes the case of very early onset of IA after LT.

کلیدواژه ها:

Invasive aspergillosis ، Liver transplantation ، Antifungal treatment